Background:

This gene is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. This gene encodes neuregulin 3 (NRG3). NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4.

Applications:

ELISA, WB, IHC

Name of antibody:

NRG3

Immunogen:

Synthetic peptide of human NRG3

Full name:

neuregulin 3

Synonyms：

HRG3; pro-NRG3

SwissProt:

P56975

ELISA Recommended dilution:

1000-2000

IHC positive control:

Human breast cancer and Human brain

IHC Recommend dilution:

50-200

WB Predicted band size:

78 kDa

WB Positive control:

Human fetal brain tissue

WB Recommended dilution:

200-1000