Background:

This gene encodes a calcium-binding protein belonging to the penta-EF-hand protein family. Calcium binding is important for homodimerization and for conformational changes required for binding to other protein partners. This gene product participates in T cell receptor-, Fas-, and glucocorticoid-induced programmed cell death. In mice deficient for this gene product, however, apoptosis was not blocked suggesting this gene product is functionally redundant. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is also located on the short arm of chromosome 5.

Applications:

ELISA, WB, IHC

Name of antibody:

PDCD6

Immunogen:

Fusion protein of human PDCD6

Full name:

programmed cell death 6

Synonyms：

ALG-2, PEF1B

SwissProt:

O75340

ELISA Recommended dilution:

1000-5000

IHC positive control:

Human ovarian cancer and human colon cancer

IHC Recommend dilution:

25-100

WB Predicted band size:

22 kDa

WB Positive control:

Jurkat and hela cells

WB Recommended dilution:

200-1000