Background:

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein.

Applications:

ELISA, IHC

Name of antibody:

UBA7

Immunogen:

Fusion protein of human UBA7

Full name:

ubiquitin-like modifier activating enzyme 7

Synonyms:

D8; UBE2; UBA1B; UBE1L

SwissProt:

P41226

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human lung cancer and human esophagus cancer

IHC Recommend dilution:

30-150