Background:

This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Applications:

ELISA, IHC

Name of antibody:

GADD45A

Immunogen:

Fusion protein of human GADD45A

Full name:

growth arrest and DNA-damage-inducible, alpha

Synonyms：

DDIT1; GADD45

SwissProt:

P24522

ELISA Recommended dilution:

1000-2000

IHC positive control:

Human brain and human cervical cancer

IHC Recommend dilution:

25-100