Background:

This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth.

Applications:

ELISA, IHC

Name of antibody:

GADD45B

Immunogen:

Fusion protein of human GADD45B

Full name:

growth arrest and DNA-damage-inducible, beta

Synonyms：

MYD118; GADD45BETA

SwissProt:

O75293

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human colon cancer and human brain

IHC Recommend dilution:

50-200