Background:

The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function.

Applications:

ELISA, IHC

Name of antibody:

NR0B2

Immunogen:

Fusion protein of human NR0B2

Full name:

nuclear receptor subfamily 0 group B member 2

Synonyms:

SHP; SHP1

SwissProt:

Q15466

ELISA Recommended dilution:

1000-2000

IHC positive control:

Human liver cancer; Human esophagus cancer