Background:

This gene encodes a protein which shares sequence similarity with other members of the type II chaperonin family. The encoded protein is a centrosome-shuttling protein and plays an important role in cytokinesis. This protein also interacts with other type II chaperonin members to form a complex known as the BBSome, which involves ciliary membrane biogenesis. This protein is encoded by a downstream open reading frame (dORF). Several upstream open reading frames (uORFs) have been identified, which repress the translation of the dORF, and two of which can encode small mitochondrial membrane proteins.

Applications:

ELISA, IHC

Name of antibody:

MKKS

Immunogen:

Fusion protein of human MKKS

Full name:

McKusick-Kaufman syndrome

Synonyms：

KMS; MKS; BBS6; HMCS

SwissProt:

Q9NPJ1

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human colon cancer and human brain

IHC Recommend dilution:

50-200