Background:

This gene encodes a member of the DNA mismatch repair mutS family. This member is a meiosis-specific protein that is not involved in DNA mismatch correction, but is required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis I. This protein and MSH5 form a heterodimer which binds uniquely to a Holliday Junction and its developmental progenitor, thus provoking ADP-ATP exchange, and stabilizing the interaction between parental chromosomes during meiosis double-stranded break repair.

Applications:

ELISA, IHC

Name of antibody:

MSH4

Immunogen:

Fusion protein of human MSH4

Full name:

mutS homolog 4

SwissProt:

O15457

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human thyroid cancer and human brain

IHC Recommend dilution:

50-200