Background:

Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. PHF21A (PHD finger protein 21A), also known as BRAF35-HDAC complex protein BHC80, is a 680 amino acid nuclear protein that contains one PHD-type zinc finger and one A.T hook DNA-binding domain, suggesting involvement in transcriptional regulation events. PHF21A is a component of the BHC complex, which is responsible for repressing transcription of neuron-specific genes in non-neuronal cells. The BHC complex acts as a chromatin modifier that deacetylates and demethylates specific sites on histones. PHF21A may act as a scaffold within the BHC complex. Predominantly expressed in brain, three isoforms of PHF21A exist as a result of alternative splicing events.

Applications:

ELISA, IHC

Name of antibody:

PHF21A

Immunogen:

Fusion protein of human PHF21A

Full name:

PHD finger protein 21A

Synonyms:

BHC80; BM-006

SwissProt:

Q96BD5

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human colorectal cancer and human ovarian cancer

IHC Recommend dilution:

40-200