Background:

Rapamycin-insensitive companion of mTOR is a protein that in humans is encoded by the RICTOR gene. RICTOR and MTOR are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth. Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors.

Applications:

ELISA, IHC

Name of antibody:

RICTOR

Immunogen:

Fusion protein of human RICTOR

Full name:

RPTOR independent companion of MTOR, complex 2

Synonyms：

PIA; AVO3; hAVO3

SwissProt:

Q6R327

ELISA Recommended dilution:

1000-5000

IHC positive control:

Human thyroid cancer and Human liver cancer

IHC Recommend dilution:

50-200