Background:

Type 1 protein phosphatase (PP1), a serine/threonine phosphatase, is highly conserved in eukaryotic cells. Four isoforms of PP1 have been characterized: PP1α, PP1δ, PP1γ1 and PP1γ2. Involvement in cell cycle regulation is one of the biological functions of PP1. It has been illustrated that PP1 dephosphorylates Rb and cdc25 during mitosis. A cell cycle-dependent phosphorylation at Thr320 of PP1α by cdc2 kinase inhibits PP1α activity.

Applications:

WB

Name of antibody:

PPP1CA

Immunogen:

Fusion protein of human PPP1CA

Full name:

protein phosphatase 1, catalytic subunit, alpha isozyme

Synonyms：

PPP1CA; MGC15877; MGC1674; PP-1A; PP1alpha; PPP1A

SwissProt:

P62136

WB Predicted band size:

38 kDa

WB Positive control:

HeLa cells

WB Recommended dilution:

500-2000