Background:

The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3' half of this gene.

Applications:

ELISA, WB

Name of antibody:

TYR

Immunogen:

Fusion protein of human TYR

Full name:

Tyrosinase

Synonyms：

CMM8; OCA1A; OCAIA; SHEP3

SwissProt:

P14679

ELISA Recommended dilution:

2000-5000

WB Predicted band size:

60 kDa

WB Positive control:

A375, Hela and Jurkat cells

WB Recommended dilution:

500-2000