Background:

The enzyme glutamate decarboxylase (GAD) is responsible for the synthesis of the essential neurotransmitter gamma-aminobutyric acid (GABA) from L-glutamic acid. GAD1 (GAD67) and GAD2 (GAD65) are expressed in nervous and endocrine systems and are thought to be involved in synaptic transmission and insulin secretion, respectively. Autoantibodies against GAD2 may serve as markers for type I diabetes. Many individuals suffering from an adult onset disorder known as Stiff Person Syndrome (SPS) also express autoantibodies to GAD2).

Applications:

WB

Name of antibody:

GAD2

Immunogen:

Fusion protein of human GAD2

Full name:

glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)

Synonyms：

GAD2; GAD65; MGC161605; MGC161607

SwissProt:

Q05329

WB Predicted band size:

65 kDa

WB Positive control:

Brain tissue

WB Recommended dilution:

500-2000