Background:

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. Proteolytic processing is required to generate a mature subunit. Expression of this gene is induced by gamma interferon, and this gene product replaces catalytic subunit 2 (proteasome beta 7 subunit) in the immunoproteasome.

Applications:

ELISA, IHC

Name of antibody:

PSMB10

Immunogen:

Fusion protein of human PSMB10

Full name:

proteasome subunit beta 10

Synonyms:

LMP10; MECL1; beta2i

SwissProt:

P40306

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human gastric cancer

IHC Recommend dilution:

100-300