Background:

This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cell membrane protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. The protein also has a role in the epithelial-to-mesenchymal transition (EMT) that characterizes the invasive phenotype associated with metastatic carcinomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Applications:

ELISA, IHC

Name of antibody:

PARD6A

Immunogen:

Fusion protein of human PARD6A

Full name:

par-6 family cell polarity regulator alpha

Synonyms：

PAR6; PAR6C; TAX40; PAR-6A; TIP-40; PAR6alpha

SwissProt:

Q9NPB6

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human colon cancer and human breast cancer

IHC Recommend dilution:

50-200