Background:

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.

Applications:

ELISA, WB, IHC

Name of antibody:

PSEN1

Immunogen:

Synthetic peptide of human PSEN1

Full name:

presenilin 1

Synonyms:

AD3; FAD; PS1; PS-1; S182

SwissProt:

P49768

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human liver cancer;

IHC Recommend dilution:

20-100

WB Predicted band size:

53 kDa

WB Positive control:

Human kidney tissue，RAW264.7 cell，Mouse kidney tissue，Mouse liver tissue lysates

WB Recommended dilution:

200-1000