Background:

The protein encoded by this gene belongs to the SEP15/selenoprotein M family. The exact function of this protein is not known; however, it has been found to associate with UDP-glucose:glycoprotein glucosyltransferase (UGTR), an endoplasmic reticulum(ER)-resident protein, which is involved in the quality control of protein folding. The association with UGTR retains this protein in the ER, where it may play a role in protein folding. It has also been suggested to have a role in cancer etiology. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene.

Applications:

ELISA, WB

Name of antibody:

SELENOF

Immunogen:

Fusion protein of human SELENOF

Full name:

selenoprotein F

Synonyms:

SEP15

SwissProt:

O60613

ELISA Recommended dilution:

5000-10000

WB Predicted band size:

18 kDa

WB Positive control:

Rat liver tissue lysate

WB Recommended dilution:

1000-5000