Background:

This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP).

Applications:

WB, IHC

Name of antibody:

MERTK/TYRO3(Phospho-Tyr749/681)

Immunogen:

Peptide sequence around phosphorylation site of tyrosine 749/681(K-I-Y(p)-S-G) derived from Human MER/SKY .

Full name:

MER proto-oncogene, tyrosine kinase/TYRO3 protein tyrosine kinase

Synonyms：

MER; RP38; c-mer/BYK; Dtk; RSE; Sky; Tif

SwissProt:

Q12866/Q06418

IHC positive control:

Human brain tissue

IHC Recommend dilution:

50-100

WB Predicted band size:

110/97 kDa

WB Positive control:

NIH/3T3 cells lysates treated with EGF

WB Recommended dilution:

500-1000