Background:

Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.When LY94 is expressed in COS-7 cells, anti-NKp46 immunoprecipitates a 46-kD surface molecule. Northern blot analysis revealed weak expression of a major transcript of 3.4 kb in spleen but in no other human tissue. Further analysis, with RT-PCR confirmation, in various lymphoid and myelomonocytic cells revealed that LY94 expression is confined to NK cells.

Applications:

ELISA, WB

Name of antibody:

NCR1

Immunogen:

Synthetic peptide of human NCR1

Full name:

natural cytotoxicity triggering receptor 1

Synonyms:

LY94; CD335; NKP46; NK-p46

SwissProt:

O76036

ELISA Recommended dilution:

5000-10000

WB Predicted band size:

34 kDa

WB Positive control:

SKOV3 cell lysate

WB Recommended dilution:

500-2000