Background:

This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. Multiple alternatively spliced transcript variants have been found for this gene.

Applications:

ELISA, IHC

Name of antibody:

PFKFB1

Immunogen:

Synthetic peptide of human PFKFB1

Full name:

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1

Synonyms：

F6PK; HL2K; PFRX

SwissProt:

P16118

ELISA Recommended dilution:

1000-5000

IHC positive control:

Human liver cancer and Human brain

IHC Recommend dilution:

50-200