Background:

This gene encodes the 50-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein is required for the stimulation of DNA polymerase delta activity by the processivity cofactor proliferating cell nuclear antigen (PCNA). Expression of this gene may be a marker for ovarian carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5.

Applications:

ELISA, WB, IHC

Name of antibody:

POLD2

Immunogen:

Fusion protein of human POLD2

Full name:

DNA polymerase delta 2, accessory subunit

SwissProt:

P49005

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human esophagus cancer

IHC Recommend dilution:

50-300

WB Predicted band size:

51 kDa

WB Positive control:

HepG2 cell lysate

WB Recommended dilution:

500-2000