Background:

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S5P family. Pseudogenes corresponding to this gene are found on chromosomes 4q, 5q, and 18q.

Applications:

ELISA, IHC

Name of antibody:

MRPS5

Immunogen:

Fusion protein of human MRPS5

Full name:

mitochondrial ribosomal protein S5

Synonyms:

S5mt; MRP-S5

SwissProt:

P82675

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human gastric cancer and Human prostate cancer

IHC Recommend dilution:

50-200