Background:

The phosphorylation of proteins by protein kinases and protein phosphatases is a key event in most nuclear and cytoplasmic processes. The ability to activate and deactivate proteins via phosphorylation or dephosphorylation is important for cell division, cell differentiation, DNA repair and transcription. STK32A (serine/threonine kinase 32A), also known as YANK1, is a 396 amino acid protein that belongs to the superfamily of serine/threonine protein kinases and exists as three isoforms. The gene encoding STK32A maps to human chromosome 5, which is associated with Cockayne syndrome through the ERCC8 gene and familial adenomatous polyposis through the adenomatous polyposis coli (APC) tumor suppressor gene. Treacher Collins syndrome is also chromosome 5 associated and is caused by insertions or deletions within the TCOF1 gene. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome. Deletion of 5q or chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.

Applications:

ELISA, WB, IHC

Name of antibody:

STK32A

Immunogen:

Fusion protein of human STK32A

Full name:

serine/threonine kinase 32A

Synonyms:

YANK1

SwissProt:

Q8WU08

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human liver cancer

IHC Recommend dilution:

100-200

WB Predicted band size:

46 kDa

WB Positive control:

Mouse heart tissue lysate

WB Recommended dilution:

500-2000