Background:

S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. Compared to TFB1M, it activates transcription of mitochondrial DNA more efficiently, while it has less methyltransferase activity.

Applications:

ELISA, IHC

Name of antibody:

TFB2M

Immunogen:

Fusion protein of human TFB2M

Full name:

transcription factor B2, mitochondrial

Synonyms:

Hkp1; mtTFB2

SwissProt:

Q9H5Q4

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human colorectal cancer

IHC Recommend dilution:

50-200