Background:

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene is considered a member of the membrane-type MMP (MT-MMP) subfamily. However, this protein is unique among the MT-MMP's in that it is a GPI-anchored protein rather than a transmembrane protein. The protein activates MMP-2 by cleavage.

Applications:

ELISA, WB

Name of antibody:

MMP17

Immunogen:

Synthetic peptide of human MMP17

Full name:

matrix metallopeptidase 17 (membrane-inserted)

Synonyms：

MT4-MMP

SwissProt:

Q9ULZ9

ELISA Recommended dilution:

2000-5000

WB Predicted band size:

58 kDa

WB Positive control:

Human colon cancer tissue

WB Recommended dilution:

500-2000