Background:

This gene encodes a protooncogene that acts as a serine/threonine protein kinase. Studies determined the encoded protein functions to prevent apoptosis and to promote cell survival. Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of a pro-apoptotic protein, BAD. Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase transcriptional activity.

Applications:

ELISA, IHC

Name of antibody:

PIM2

Immunogen:

Fusion protein of human PIM2

Full name:

pim-2 oncogene

SwissProt:

Q9P1W9

ELISA Recommended dilution:

1000-5000

IHC positive control:

Human thyroid cancer

IHC Recommend dilution:

50-200