Background:

PAPP A was originally isolated from pregnancy serum as heterotetrameric protein complex with molecular weight approximately 500 kDa, consisting of two PAPP A subunits disulfide-linked with two subunits of the proform of eosinophil major basic protein (proMBP). In such a complex proMBP functions as an inhibitor of PAPP A proteinase activity. PAPP A is widely used as a marker of some pathologies during pregnancy. Reduced level of PAPP A in pregnancy blood in the first trimester is associated with fetal Down syndrome. PAPP A is considered as one of the best biochemical markers in early pregnancy used to screen for Down syndrome during the first trimester (Wald, N. J. et al).

Applications:

ELISA, IHC

Name of antibody:

PAPPA-AS1

Immunogen:

Synthetic peptide of human PAPPA-AS1

Full name:

PAPPA antisense RNA 1

Synonyms:

DIPAS; TAF4B; PAPPAS; TAF2C2; PAPPAAS; PAPPA-AS; TAFII105; NCRNA00156

SwissProt:

Q5QFB9

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human tonsil

IHC Recommend dilution:

20-100