Background:

This gene encodes an acetylhydrolase that catalyzes the removal of an acetyl group from the glycerol backbone of platelet-activating factor. The encoded enzyme is a subunit of the platelet-activating factor acetylhydrolase isoform 1B complex, which consists of the catalytic beta and gamma subunits and the regulatory alpha subunit. This complex functions in brain development. A translocation between this gene on chromosome 19 and the CDC-like kinase 2 gene on chromosome 1 has been observed, and was associated with cognitive disability, ataxia, and atrophy of the brain. Alternatively spliced transcript variants have been described.

Applications:

ELISA, WB, IHC

Name of antibody:

PAFAH1B3

Immunogen:

Fusion protein of human PAFAH1B3

Full name:

platelet activating factor acetylhydrolase 1b catalytic subunit 3

Synonyms:

PAFAHG

SwissProt:

Q15102

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human liver cancer and Human colorectal cancer

IHC Recommend dilution:

50-200

WB Predicted band size:

26 kDa

WB Positive control:

Human fetal brain tissue lysate

WB Recommended dilution:

1000-5000