Background:

The protein encoded by this gene is a member of the family of soluble N-ethylmaleimide-sensitive fusion protein-attachment protein receptors (SNAREs) that function in intracellular trafficking. This family member is involved in vesicular transport between endosomes and the trans-Golgi network. It is a vesicle-associated SNARE (v-SNARE) that interacts with target membrane SNAREs (t-SNAREs). Polymorphisms in this gene have been associated with binocular function, and also with susceptibility to colorectal and lung cancers. A recurrent rearrangement has been found between this gene and the transcription factor 7-like 2 (TCF7L2) gene in colorectal cancers. Alternative splicing results in multiple transcript variants.

Applications:

ELISA, WB, IHC

Name of antibody:

VTI1A

Immunogen:

Full length fusion protein

Full name:

vesicle transport through interaction with t-SNAREs 1A

Synonyms:

MMDS3; MVti1; VTI1RP2; Vti1-rp2

SwissProt:

Q96AJ9

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human esophagus cancer

IHC Recommend dilution:

25-100

WB Predicted band size:

25 kDa

WB Positive control:

231,Jurkat,Hela and HEPG2 cell lysates

WB Recommended dilution:

200-1000