Background:

Ubiquitin (see MIM 191339)-dependent proteolysis is a complex pathway of protein metabolism implicated in such diverse cellular functions as maintenance of chromatin structure, receptor function, and degradation of abnormal proteins. A late step of the process involves disassembly of the polyubiquitin chains on degraded proteins into ubiquitin monomers. USP5 disassembles branched polyubiquitin chains by a sequential exo mechanism, starting at the proximal end of the chain (Wilkinson et al., 1995 [PubMed 7578059]).

Applications:

ELISA, IHC

Name of antibody:

USP5

Immunogen:

Fusion protein of human USP5

Full name:

ubiquitin specific peptidase 5 (isopeptidase T)

Synonyms：

ISOT

SwissProt:

P45974

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human thyroid cancer and Human esophagus cancer

IHC Recommend dilution:

25-100