Background:

This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.

Applications:

ELISA, IHC

Name of antibody:

TYK2

Immunogen:

Fusion protein of human TYK2

Full name:

tyrosine kinase 2

Synonyms:

JTK1; IMD35

SwissProt:

P29597

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human liver cancer and Human thyroid cancer

IHC Recommend dilution:

150-300