Background:

This gene encodes a member of the thioredoxin superfamily. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. This protein localizes to the endoplasmic reticulum and has a single atypical active motif. The encoded protein is mainly involved in catalyzing native disulfide bond formation and displays activity similar to protein-disulfide isomerases. This protein may play a role in defense against endoplasmic reticulum stress. Alternate splicing results in both coding and non-coding variants.

Applications:

ELISA, IHC

Name of antibody:

TXNDC12

Immunogen:

Fusion protein of human TXNDC12

Full name:

thioredoxin domain containing 12

Synonyms:

AG1; AGR1; ERP16; ERP18; ERP19; TLP19; hAG-1; PDIA16; hTLP19

SwissProt:

O95881

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human colorectal cancer and Human liver cancer

IHC Recommend dilution:

50-200