Background:

Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA exerts its effects through ionotropic [GABA(A/C)] receptors, to produce fast synaptic inhibition, and metabotropic [GABA(B)] receptors, to produce slow, prolonged inhibitory signals. The GABA(B) receptor consists of a heterodimer of two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene generates multiple transcript variants.

Applications:

ELISA, IHC

Name of antibody:

GABBR1

Immunogen:

Synthetic peptide of human GABBR1

Full name:

gamma-aminobutyric acid (GABA) B receptor, 1

Synonyms：

GB1; GPRC3A; GABABR1; GABBR1-3; dJ271M21.1.1; dJ271M21.1.2

SwissProt:

Q9UBS5

ELISA Recommended dilution:

1000-2000

IHC positive control:

Human thyroid cancer

IHC Recommend dilution:

25-100