Background:

This gene encodes an essential regulator of mitochondrial Ca2+ uptake under basal conditions. The encoded protein interacts with the mitochondrial calcium uniporter, a mitochondrial inner membrane Ca2+ channel, and is essential in preventing mitochondrial Ca2+ overload, which can cause excessive production of reactive oxygen species and cell stress. Alternatively spliced transcript variants encoding different isoforms have been described.

Applications:

ELISA, IHC

Name of antibody:

MICU1

Immunogen:

Fusion protein of human MICU1

Full name:

mitochondrial calcium uptake 1

Synonyms:

CALC; EFHA3; MPXPS; CBARA1

SwissProt:

Q9BPX6

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human lung cancer and human prostate cancer

IHC Recommend dilution:

30-150