Background:

The protein encoded by this gene is part of a complex that relieves repressive chromatin structures, allowing the transcriptional machinery to access its targets more effectively. The encoded nuclear protein may also bind to and enhance the DNA joining activity of HIV-1 integrase. This gene has been found to be a tumor suppressor, and mutations in it have been associated with malignant rhabdoid tumors. Two transcript variants encoding different isoforms have been found for this gene.

Applications:

ELISA, WB, IHC

Name of antibody:

SMARCB1

Immunogen:

Fusion protein of human SMARCB1

Full name:

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1

Synonyms：

RDT; INI1; SNF5; Snr1; BAF47; MRD15; RTPS1; Sfh1p; hSNFS; SNF5L1; SWNTS1; PPP1R144

SwissProt:

Q12824

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human breast cancer and human brain

IHC Recommend dilution:

25-100

WB Predicted band size:

44 kDa

WB Positive control:

Hepg2, K562 and Jurkat cells

WB Recommended dilution:

500-2000